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An itchy and red rash is a common indication of an allergic reaction, particularly in response to new medications. This type of rash often occurs due to the body's immune response to what it perceives as a foreign substance, leading to inflammation and the release of histamines. The itchy sensation is a result of irritation in the skin, which can manifest as redness and swelling in the affected area.

Other types of rashes, such as dry and flaky, smooth and pale, or blistering, might be associated with different skin conditions or reactions that are not directly linked to allergies. For instance, a dry and flaky rash may suggest skin irritation or a dermatological condition like eczema, while a smooth and pale rash could indicate a lack of blood flow or another health issue unrelated to an allergen. A blistering rash, while it can be severe and painful, often points to conditions such as infections or irritant contact dermatitis rather than a straightforward allergic reaction. Therefore, the characteristics of the rash—the itchiness and redness—serve as key indicators that suggest an allergic response to newly introduced medications.